7 8 The common clustering of these risk factors in a single individual has been called the metabolic syndrome. 5 6 Insulin resistance typically precedes the onset of type 2 diabetes and is commonly accompanied by other cardiovascular risk factors: dyslipidemia, hypertension, and prothrombotic factors. 1 2 Insulin secretion declines with advancing age, 3 4 and this decline may be accelerated by genetic factors. Insulin resistance develops from obesity and physical inactivity, acting on a substrate of genetic susceptibility. The underlying metabolic causes of type 2 diabetes are the combination of impairment in insulin-mediated glucose disposal (insulin resistance) and defective secretion of insulin by pancreatic β-cells. This disorder typically makes its appearance later in life. The most prevalent form of diabetes mellitus is type 2 diabetes. Customer Service and Ordering InformationĬlinical Presentations of Diabetes Mellitus.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes. ![]() Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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